Ortiz turned professional later in 2004 while still only seventeen years of age.
After turning professional, Ortiz easily won his first seven fights against weak opposition. However, in 2005, Ortiz was controversially disqualified in the first round of a bout against unknown Corey Alarcon. After having already knocked Alarcon down once in the round, Ortiz knocked him down again shortly after the referee ordered the fighters to separate from a clinch. Alarcon stayed down for the count, and was awarded the fight based on Denkin's judgment that Ortiz's knockout punch had been an illegal punch during a break.
In 2009, Ortiz faced Marcos Rene Maidana (25-1-0) of Argentina for the interim WBA World light welterweight title. Ortiz entered the fight with an eight-fight knockout streak. Maidanais a dangerous puncher who had won 25 of his 26 previous bouts by knockout. Both Ortiz and Maidana were knocked down in the first round. Ortiz knocked Maidana to the canvas twice in the second round. Ortiz suffered a cut in the 5th round and was knocked down in the 6th round. The fight was stopped after Ortiz was taken to the ringside doctor where it was ruled he could no longer continue due to the swelling in one eye and the deep cut in the other.
In April 2011, Ortiz fought Andre Berto for the WBC welterweight title. Hailed as the early pick for the Fight of the Year, Ortiz won the fight by unanimous decision over Berto. Berto and Ortiz exchanged knockdowns with both of them going down twice. However, Ortiz gave more punishment than he recieved. The judges scored the match 115-110, 114-112 and 114-111 all for Victor Ortiz - the new WBC welterweight champion.
UD 12 Andre Berto - 2011
KO 3 Vivian Harris - 2010
W12 Nate Campbell - 2010
KO 1 Carlos Maussa - 2007
KO 4 Floyd Mayweather Jr -2011
KO 6 Marcos Maidana - 2009