The bout will be aired live on Sky Sports.
The 35 year old Froch, now a three-time World Champion, is fresh off his dominating performance against Lucian Bute in May.
But Yusef Mack (31-4-2, 17 KO), who hails from Philadelphia, is no stranger to fighting big names. In 2009, he won a split decision over rising star Chris Henry (then 23-1) before being stopped by aging tough man Glen Johnson in 2010. Although he was TKO'd by undefeated light heavyweight champion Tavoris Cloud last year, he's 2-0 this year, defeating the likes of Sabou Ballogou (then 8-5-0) and Omar Sheika (then 32-11).
Known as 'Mack Attack,' Yusaf, who often campaigns as a light heavyweight, is ranked No. 15 in the division by BoxRec.
"I can't wait to get back into that ring in Nottingham and give the fans another great night," said Carl Froch.
"The Bute win will go down as one of the greatest nights of my life and I plan on doing something special against Mack on November 17. He's got nothing to lose coming here to face me and I know he'll put it all on the line to take the title from me so I'll be fully prepared for everything he's got and I'll be hitting him with all my best."
"I'm delighted to have to have secured a home defence for Carl, no-one deserves if more," said promoter Eddie Hearn. "He will be fully focused on the fight with Mack, a much bigger man who will be coming to rip that World title from his grasp. I can't wait to be there on the night with the British fans sure to create another electric atmosphere in the Capital FM Arena."
This bout should be little more than a tune-up for Carl Froch who is seeking superfights down the road, including rematches with Lucian Bute, Andre Ward and Mikkel Kessler and possibly a title unification bout against newly-crowned WBO Super Middleweight "King" Arthur Abraham.
Expect a Carl Froch win. The real question is: Will he look dazzling against Mack, a rugged journeyman who is capable of spoiling any champion's homecoming?