The scores were 115-107 three ways.
Fresh off his one-sided win over Winky Wright earlier this year, the 6'1" fighter of Cuban fighter floored his Cameron-born French foe twice in Round 4 and Round 6 and added yet another deuce in the 12th and final round.
All but one knockdown were generated compliments of Peter Quillin's sharp left hook.
Despite "Kid Chocolate's" knockdowns and the wide score, the bout was competitive as Quillin appeared to have carried only six of the 12 rounds.
With the victory, the 29 year old Quillin joins lineal middleweight champion Sergio Martinez as well as Gennady Golovkin and Daniel Geale as one of four middleweights who hold major world titles.
Perhaps tonight's crowd-pleasing yet somewhat vulnerable performance by both fighters will draw the ire of some bigger names for Quillin and N'Jikam going forward?
The stubborn N'Jikam, who came up short for the first time in 27 bouts, showed a lot of grit and courage, fighting back hard whenever he was stung.
In a more subdued affair, Devon Alexander (24-1, 13 KOs) won a rather plane twelve round unanimous decision over power-puncher Randall Bailey (43-8, 37 KOs) to claim the IBF welterweight belt.
Non unlike his bouts against Maidana and Matthysse, Alexander jabbed well, utilized fine foot work and clinched and held in between to smoother Bailey and seal the deal. The scores were 115-111, 116-110 and 117-109 in favor of St. Louis's Alexander.