And he did it with one punch - his pulverizing left hook.
With that mighty punch, Donaire overcame the odds to become the new IBF Flyweight king.
Not only did the bout put Nonito on boxing's radar, the fight subsequently earned honors as RING's Magazine's 'Knockout of the Year' and 'Upset of the Year.'
Nonito Donaire's crushing left hook is reminiscent of the Thomas Hearns right cross of the 1980s.
The term 'pound for pound' is used in boxing to describe a fighter's abilities in relation to other fighters of different weight classes.
As these fighters do not compete directly, judging the best fighters pound for pound is subjective to numerous criteria and interpretation. We often hypothesize and classify the best pound-for-pound fighters in the sport but seldom do we discuss the best pound-for-pound punch.
If there is such a thing as the most devastating punch pound-for-pound, Nonito Donaire's left hook gets top honors.
Simply put, it's the most feared, most devastating punch in boxing, pound-for-pound.
It was scary enough when Thomas Hearns, a 147 lb welterweight, could anesthetize opponents with one straight right - The same right that twice floored Sugar Ray Leonard and put many opponents to sleep. And Donaire does the same thing at even lower weights.
After Nonito Donaire knocked out Fernando Montiel with his signature left hook in 2011, the 'Filipino Flash' told reporters it was the hardest punch he had ever thrown. And many at ringside didn't argue his claim.
Moreover, even Montiel's supporters were overheard saying that Nonito's spectacular left hook may have been one of the hardest punches landed in the entire history of the 118 lb division.
In his title unification bout against the steel-chinned Jeffrey Mathebula last summer, Donaire dropped his foe the first time in Mathebula's career with a counter left hook in the final seconds of Round 4. Mathebula arose at the count of seven and staggered to his corner as the round had ended.
After the bout, Mathebula was treated for a broken jaw which was likely caused by... a Donaire left hook.
By the time Nonito Donaire fought Toshiaki Nishioka in October 2012, the Flash's left hook was a secret no more.
Its not surprising that Nishioka, who was the most accomplished Jr Featherweight in recent memory entering his showdown with Donaire, had his right hand glued to the side of his head to protect against Donaire's vaunted warhead.
Moreover, the Japanese superstar seemed reluctant to unleash his best punch, a southpaw-style straight left hand, for fear of the incoming artillery he might receive in response.
Donaire eventually finished Nishioka with a counter right off a lazy jab Round 9. Valiantly, the Japanese fighter arose but absorbed a nasty left uppercut and the bout was halted. Nishi's corner ended it.
In front of a pro-Mexican crowd of 7,200+, Donaire outclassed Arce Rounds 1 and 2 before ending matters in the third. At 2:59 of Round 3, Donaire dropped his mind-numbing left hook, flooring his foe for longer than a 10 count.
"My left hook was my damaging punch," Donaire said after successfully defending his RING junior featherweight championship. "It was very strong. I could land it when I wanted to land it."
And despite dropping a unanimous decision to fellow Top 10 pound-for-pound sensation Guillermo Rigondeaux last April, Donaire floored his hard-to-hit foe in Round 10 with that brilliant left hook.
Not only is Nonito Donaire's left hand spell-binding, he unleashes it with speed, precision and from numerous angles.
How will Vic cope with the most devastating weapon in boxing today?