Now the question is who will he fight next?
Danny Garcia- Garcia was impressive in his 12 round unanimous decision over Lucas Matthysse on the Mayweather vs. Canelo undercard.
Since some felt the winner of Garcia vs. Matthysse would be the next in line to face Mayweather, Garcia is seen as the next likely opponent. A Mayweather vs. Garcia matchup would be another chance to build the fight with two undefeated fighters.
But after the way Mayweather disposed of another young fighter in Canelo, Garcia's team may want to wait until they see Mayweather slowing down before challenging the pound for pound king.
Amir Khan- Khan has been discussed as a possible opponent for Mayweather for years, especially since Mayweather expressed interest in fighting in the UK. But every time Khan was in line for a shot at Mayweather he would lose, most noticeably his knockout loss to Danny Garcia in July of 2012.
But if Khan is able to defeat Devon Alexander it could earn him a direct shot at Mayweather. What makes Khan an attractive opponent for Mayweather is the money he brings in from the UK and a suspect chin, which could lead to the 27th knockout of Mayweather's career.
Sergio Martinez- Martinez has also been mentioned as a possible candidate for Mayweather over the last few years. At one time, Martinez stated he could come down to 150 pounds to fight Mayweather. Since Mayweather just defeated a much larger man in Canelo, he may decide to move up in weight and challenge Martinez for the middleweight championship.
If Mayweather were to challenge Martinez, it would give him the opportunity to win a title in six different weight classes which would add to his legacy.
Manny Pacquiao- Mayweather vs. Pacquiao will probably never happen. One reason is the feud between Mayweather and Pacquiao's promoter Bob Arum. Another reason is this potential mega fight has lost all of its luster after Pacquiao was knocked out cold by Juan Manuel Marquez.
But if Pacquiao is able to defeat Brandon Rios later this year and if Arum and Pacquaio acquiesce to Mayweather's demands on the fight details, anything is possible. Even though the fight will not be what it could have been if they fought years earlier, it's still a big fight that fans have been wanting to see since 2009.